FITC Anti-DR4 antibody [DR-4-02],Abcam,AB59047

Do not use after expiration date stamped on vial label.Short term exposure to room temperature should not affect the quality of the reagent. However, if reagent is stored under any conditions other than those specified, the conditionsmust be verified by the user. Soluble antibody blocks DR4 receptor against TRAIL induced apoptosis. Plastic immobilized antibody induces apoptosis in sensitive cells. The purified antibody is conjugated with Fluorescein isothiocyanate (FITC) under optimum conditions. The reagent is free of unconjugated FITC and adjusted for direct use. No reconstitution is necessary.

Host

Mouse

Reactivity

Human

Application

Flow Cyt, FuncS, IP

Conjugate

FITC

Platform ID

BAB305897450

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Abcam

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Email:

[email protected]

Product Specifications
Scientific Background

Specifications

NameFITC Anti-DR4 antibody [DR-4-02]
Cat. No.AB59047
HostMouse
IsotypeIgG1
ReactivityHuman
ConjugationFITC
ApplicationFlow Cyt, FuncS, IP
ClonalityMonoclonal
Clone NumberDR-4-02
Concentration0.1 mg/mL Batch dependent concentration
ImmunogenRecombinant Fragment Protein within Human TNFRSF10A. The exact immunogen used to generate this antibody is proprietary information.
PuritySize-exclusion chromatography
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7.4 Preservative: 0.097% Sodium azide Constituents: 0.2% BSA
Storage+4°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Receptor for the cytotoxic ligand TNFSF10/TRAIL (PubMed : 26457518, PubMed : 38532423). The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis (PubMed : 19090789). Promotes the activation of NF-kappa-B (PubMed : 9430227). See full target information TNFRSF10A

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