FITC Anti-Integrin beta 4 antibody [450-9D],Abcam,AB22486

Host

Mouse

Reactivity

Human

Application

IHC-Fr

Conjugate

FITC

Platform ID

BAB681484668

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Abcam

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Email:

[email protected]

Product Specifications
Scientific Background

Specifications

NameFITC Anti-Integrin beta 4 antibody [450-9D]
Cat. No.AB22486
HostMouse
IsotypeIgG1
ReactivityHuman
ConjugationFITC
ApplicationIHC-Fr
ClonalityMonoclonal
Clone Number450-9D
Concentration0.1 mg/mL Batch dependent concentration
ImmunogenNative Full Length Protein corresponding to Human ITGB4.
PurityAffinity purification Protein G
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7.4 Preservative: 0.1% Sodium azide Constituents: PBS, 1% BSA
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility. ITGA6 : ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed : 20682778). ITGA6 : ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed : 22351760). ITGA6 : ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling (PubMed : 28873464). See full target information ITGB4

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