FITC Anti-Myeloperoxidase antibody [2C7],Abcam,AB11729

What is this antibody validated in? FITC Anti-Myeloperoxidase antibody [2C7] (ab11729) is a mouse monoclonal antibody and is validated for use in Flow Cytometry (Intra), Flow Cytometry (Flow Cyt) in Human samples. Trusted by the scientific community Anti-Myeloperoxidase [2C7] FITC (ab11729) was first used in a scientific publication in 2004 and has been cited over 10 times in peer-reviewed journals. Related products Antibody clone 2C7 is also available pre-conjugated to a variety of labels for your convenience – Anti-Myeloperoxidase FITC [2C7] (ab11729). Other related products We have a range of other formats of antibody clone [2C7] also available for your convenience: ab283263 , Carrier free - ab283284 , FITC - ab11729, PE - ab11730

Host

Mouse

Reactivity

Human

Application

Flow Cyt (Intra)

Conjugate

FITC

Platform ID

BAB931909464

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Product Specifications
Scientific Background

Specifications

NameFITC Anti-Myeloperoxidase antibody [2C7]
Cat. No.AB11729
HostMouse
IsotypeIgG1
ReactivityHuman
ConjugationFITC
ApplicationFlow Cyt (Intra)
ClonalityMonoclonal
Clone Number2C7
Concentration0.1 mg/mL Batch dependent concentration
ImmunogenRecombinant Full Length Protein corresponding to Human MPO.
PurityAffinity purification Protein G
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7.4 Preservative: 0.09% Sodium azide Constituents: PBS, 1% BSA
Storage+4°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity (PubMed : 9922160). Mediates the proteolytic cleavage of alpha-1-microglobulin to form t-alpha-1-microglobulin, which potently inhibits oxidation of low-density lipoprotein particles and limits vascular damage (PubMed : 25698971). See full target information MPO

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