FITC Anti-Rhodopsin antibody [4D2],Abcam,AB183399

Host

Mouse

Conjugate

FITC

Platform ID

BAB307296778

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Abcam

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Email:

[email protected]

Product Specifications
Scientific Background

Specifications

NameFITC Anti-Rhodopsin antibody [4D2]
Cat. No.AB183399
HostMouse
IsotypeIgG1
ConjugationFITC
ClonalityMonoclonal
Clone Number4D2
Concentration1 mg/mL Batch dependent concentration
ImmunogenRecombinant Fragment Protein within Cow Rhodopsin. The exact immunogen used to generate this antibody is proprietary information.
PurityAffinity purification Protein G
Appearance/FormLiquid
ShippingBlue Ice
FormulationPreservative: 0.09% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Storage+4°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth (By similarity). Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change that activates signaling via G-proteins (PubMed : 10926528, PubMed : 11972040, PubMed : 12044163, PubMed : 16586416, PubMed : 16908857, PubMed : 17060607, PubMed : 17449675, PubMed : 18818650, PubMed : 21389983, PubMed : 22198838, PubMed : 23579341, PubMed : 25205354, PubMed : 27458239). Subsequent receptor phosphorylation mediates displacement of the bound G-protein alpha subunit by the arrestin SAG and terminates signaling (PubMed : 1396673, PubMed : 15111114). See full target information Rhodopsin

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