FITC anti-mouse CD49b Antibody anti-CD49b - HMα2,BioLegend,103504
Additional reported applications (for the relevant formats) include: immunoprecipitation1, immunofluorescence on frozen sections4, and blocking of cell adhesion1-3. The Ultra-LEAF™ purified antibody (Endotoxin < 0.01 EU/μg, Azide-Free, 0.2 μm filtered) is recommended for functional assays (Cat. No. 103525 & 103526).
Host
Armenian Hamster
Reactivity
Mouse
Application
FC - Quality tested
Platform ID
BAB548904659
BioLegend
Contact
Tel: 1-858-455-9588
Fax: +49 (4131) 7023913
Email:
Specifications
Scientific Background
CD49b is a 150 kD glycoprotein, also known as α2integrin, VLA-2 α chain, Integrin α2chain, and HMα2. It is a member of the integrin family, expressed on NK cells, a subset of splenic CD4+T cells, NK-T cells, intestinal intraepithelial and lamina propria lymphocytes, epithelial cells, and platelets. By associating with CD29 (integrin β1subunit), CD49b forms the VLA-2 (integrin α2β1) complex. It plays a critical role in both adhesion and lymphocyte activation. The primary ligands for CD49b are collagen, laminin, and fibronectin. The HMα2 antibody has been shown to be useful for partially blocking CD49b mediated interactions with collagen. Additionally, this antibody blocks staining of splenic NK cells by the monoclonal antibody DX5.
Category Paths
- Products>Primary Antibodies>Monoclonal Antibodies
Please provide the required information below so that we can quickly source your products.