Factor XIIIA (E980.1) Mouse Monoclonal Antibody#84321,Cell Signaling Technology (CST),84321

Factor XIIIA, or fibrin stabilizing factor, is activated by thrombin and Ca2+to a protransglutaminase in the final step of the blood coagulation cascade that cross-links fibrin chains (1). This enzyme catalyzes the gamma-glutamyl-epsilon-lysine cross-linking between fibrin molecules, stabilizing the fibrin clot (1,2). It is widely expressed in dermal dendritic cells (3). High expression of Factor XIIIA positive cells can be indicative of inflammatory conditions such as lichen planus and psoriasis (4).Muszbek, L. et al. (1996)Crit Rev Clin Lab Sci33, 357-421.Cleary, D.B. and Maurer, M.C. (2006)Biochim Biophys Acta1764, 1207-17.Cerio, R. et al. (1989)Br J Dermatol121, 421-31.Deguchi, M. et al. (2002)Arch Dermatol Res294, 297-302.Alternate NamesbA525O21.1 (coagulation factor XIII, A1 polypeptide); Coagulation factor XIII A chain; coagulation factor XIII A1 subunit; coagulation factor XIII, A polypeptide; coagulation factor XIII, A1 polypeptide; Coagulation factor XIIIa; F13A; F13A1; factor XIIIa; fibrin stabilizing factor, A subunit; fibrinoligase; FSF, A subunit; Protein-glutamine gamma-glutamyltransferase A chain; TGase; Transglutaminase A chain; transglutaminase. plasma

bA525O21.1 (coagulation factor XIII, A1 polypeptide); Coagulation factor XIII A chain; coagulation factor XIII A1 subunit; coagulation factor XIII, A polypeptide; coagulation factor XIII, A1 polypeptide; Coagulation factor XIIIa; F13A; F13A1; factor XIIIa; fibrin stabilizing factor, A subunit; fibrinoligase; FSF, A subunit; Protein-glutamine gamma-glutamyltransferase A chain; TGase; Transglutaminase A chain; transglutaminase. plasma