Fc-gammaRIII/CD16 (F6K6G) Rabbit Monoclonal Antibody#71345,Cell Signaling Technology (CST),71345

CD64 (FcgammaRI), CD32 (FcgammaRII), and CD16 (FcgammaRIII) are three classes of the immunoglobulin superfamily. CD64 has a high affinity for IgG with three Ig-like domains while CD32 and CD16 have low affinities with two Ig-like domains. Two genes encode CD16-A and CD16-B resulting only in a 6 amino acid difference in their ectodomains. However, CD16-A has a transmembrane anchor versus CD16-B, which has a glycosylphosphatidylinositol (1). CD64, CD32, and CD16 are membrane glycoproteins that are expressed by all immunologically active cells and trigger various immune functions (activate B cells, phagocytosis, antibody-dependent cellular cytotoxicity, immune complex clearance, and enhancement of antigen presentation) (2). CD16 cross-linking induces tyrosine phosphorylation (Tyr394) of Lck in NK cells (3). CD32 has tyrosine-based activation motifs in the cytoplasmic domain in contrast to CD16, which associates with molecules possessing these motifs (1).Mouse CD16 (FcgammaRIII) is widely expressed across many tissue types and in macrophages, stimulation with IFN-γ increases expression (4). Mouse CD16 has been shown to bind with mouse IgG1, IgG2a, and IgG2b (4).Maenaka, K. et al. (2001)J. Biol. Chem.276, 44898-44904.Fridman, W. H. et al. (1992)Immunol. Rev.125, 49-76.Pignata, C. et al. (1993)J. Immunol.151, 6794-6800.Hirano, M. et al. (2007)Nat Immunol8, 762-71.Alternate NamesCD16; Fc gamma receptor III; Fc receptor, IgG, low affinity III; Fc-gamma RIII; Fcg receptor III; Fcgam; FcgammaRIII; FCGR2A; Fcgr3; FcRIII; IgG Fc receptor III; Low affinity immunoglobulin gamma Fc region receptor III

CD16; Fc gamma receptor III; Fc receptor, IgG, low affinity III; Fc-gamma RIII; Fcg receptor III; Fcgam; FcgammaRIII; FCGR2A; Fcgr3; FcRIII; IgG Fc receptor III; Low affinity immunoglobulin gamma Fc region receptor III