FoxK1 Antibody#12025,Cell Signaling Technology (CST),12025

Forkhead box (Fox) proteins are a family of evolutionarily conserved transcription factors defined by the presence of a winged helix DNA-binding domain called a Forkhead box (1). In humans, there are over 40 known Fox protein family members, divided into 19 subfamilies, which have evolved to regulate gene transcription in diverse and highly specialized biological contexts throughout development (2). Mutations that disrupt the expression of Fox gene family members have consequently been implicated in a broad array of human disorders, including immunological dysfunction, infertility, speech/language disorders, and cancer (3,4).FoxK1 belongs to a subfamily of Fox proteins along with FoxK2. FoxK1 functions as a transcriptional repressor of downstream target genes, includingFoxO4,Mef2,p21,PPGB, andACTA2(5-7). There are two isoforms of FoxK1: FoxK1-α and FoxK1-β. The β isoform has a truncated C terminus compared to the α isoform. The two isoforms of FoxK1 show reciprocal expression patterns during muscle regeneration. FoxK1-β is expressed mainly in quiescent satellite cells (8), whereas FoxK1-α is the dominant isoform in proliferating myoblasts from activated satellite cells (9). Both isoforms of FoxK1 jointly regulate proliferation and differentiation of myogenic stem cells during development and muscle regeneration (10).Myatt, S.S. and Lam, E.W. (2007)Nat Rev Cancer7, 847-59.Jackson, B.C. et al. (2010)Hum Genomics4, 345-52.Hannenhalli, S. and Kaestner, K.H. (2009)Nat Rev Genet10, 233-40.Benayoun, B.A. et al. (2011)Trends Genet10, 224-32.Hawke, T.J. et al. (2003)J Biol Chem278, 4015-20.Freddie, C.T. et al. (2007)Nucleic Acids Res35, 5203-12.Shi, X. et al. (2012)J Cell Sci125, 5329-37.Garry, D.J. et al. (1997)Dev Biol188, 280-94.Yang, Q. et al. (1997)Mol Cell Biol17, 5236-43.Garry, D.J. et al. (2000)Proc Natl Acad Sci USA97, 5416-21.Alternate NamesFLJ14977; forkhead box K1; Forkhead box protein K1; FOXK1; FOXK1L; MNF; Myocyte nuclear factor

FLJ14977; forkhead box K1; Forkhead box protein K1; FOXK1; FOXK1L; MNF; Myocyte nuclear factor