GDNF Receptor alpha 2 antibody,Genetex,GTX74268

Host

Rabbit

Reactivity

Human, Mouse, Rat

Application

WB ICC/IF

Conjugate

Unconjugated

Platform ID

BAB111958172

Genetex

Headquarters

2456 Alton Pkwy Irvine, CA 92606 USA

Genetex

Contact

Tel: 1-949-553-1900
Fax: 1-949-309-2888

Email:

[email protected]

Product Specifications
Scientific Background
Synonyms

Specifications

NameGDNF Receptor alpha 2 antibody
Cat. No.GTX74268
Gene ID (Entrez)2675
HostRabbit
IsotypeIgG
ReactivityHuman, Mouse, Rat
ConjugationUnconjugated
ApplicationWB ICC/IF
ClonalityPolyclonal
Concentration0.5 mg/ml (Please refer to the vial label for the specific concentration.)
TargetGFRA2
ImmunogenSynthetic peptide from C-terminus of human GFR alpha-2
PurityPurified by ion exchange chromatography
Appearance/FormLiquid
FormulationPBS,0.02% Sodium azide
StorageStore as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Regulatory StatusResearch Use Only

Scientific Background

Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This encoded protein acts preferentially as a receptor for NTN compared to its other family member, GDNF family receptor alpha 1. This gene is a candidate gene for RET-associated diseases. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

Synonyms

GDNF family receptor alpha 2 , GDNFRB , NRTNR-ALPHA , NTNRA , RETL2 , TRNR2

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