GMP PerCP/Cyanine5.5 anti-human CD64, CD64, 10.1,BioLegend,260444
Clone 10.1 recognizes the EC3 epitope of CD64. While both contain the EC3 domain, in-house testing suggests that clone 10.1 preferentially binds to CD64A (FcγRIA), but not CD64B (FcγRIB). Additional reported applications (for the relevant formats) include: blocking of human IgG3 and murine IgG2a binding to FcγRI2,5,6,11and immunohistochemical staining of acetone-fixed frozen tissue sections12.
Host
Mouse
Application
FC - Quality tested
Platform ID
BAB778516921
BioLegend
Contact
Tel: 1-858-455-9588
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Product Specifications
Scientific Background
Specifications
NameGMP PerCP/Cyanine5.5 anti-human CD64, CD64, 10.1
Cat. No.260444
HostMouse
IsotypeMouse IgG1, κ
ApplicationFC - Quality tested
ClonalityMonoclonal
Clone Number10.1
Concentration200 µg/mL
TargetCD64
ImmunogenHuman rheumatoid synovial fluid cells and fibronectin-purified monocytes.
PurityThe antibody was purified by affinity chromatography and conjugated with PE/Cyanine5.5 under optimal conditions.
FormulationPhosphate-buffered solution, pH 7.2, containing True-Stain Monocyte Blocker™, 0.09% sodium azide and 0.2% (w/v) BSA (origin USA) and a stabilizer.
StorageThe antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light.Do not freeze.
Regulatory StatusResearch Use Only
Scientific Background
CD64 is a 72 kD single chain type I glycoprotein also known as FcγRI and FcR I. CD64 is a member of the immunoglobulin superfamily and is expressed on monocytes/macrophages, dendritic cells, and activated granulocytes. The expression can be upregulated by IFN-γ stimulation. CD64 binds IgG immune complex. It plays a role in antigen capture, phagocytosis of IgG/antigen complexes, and antibody-dependent cellular cytotoxicity (ADCC).
Category Paths
- Products>Primary Antibodies>Monoclonal Antibodies
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