GRAP (F9U7T) Rabbit Monoclonal Antibody#51888,Cell Signaling Technology (CST),51888

GRAP (F9U7T) Rabbit Monoclonal Antibody recognizes endogenous levels of total GRAP protein. This antibody does not cross-react with GRB2 protein.

Host

Rabbit

Reactivity

Human, Mouse

Application

Western Blotting: 1:1000 Immunoprecipitation: 1:50

Platform ID

BAB604544146

Cell Signaling Technology (CST)

Headquarters

3 Trask Lane Danvers, MA 01923

Cell Signaling Technology (CST)

Contact

Tel: 877-616-2355,978-867-2388
Fax: 877-616-2355

Email:

[email protected]

Product Specifications
Scientific Background
Synonyms

Specifications

NameGRAP (F9U7T) Rabbit Monoclonal Antibody#51888
Cat. No.51888
Accession NumberQ13588
Gene ID (Entrez)13588, 10750
HostRabbit
SensitivityEndogenous
ReactivityHuman, Mouse
ApplicationWestern Blotting: 1:1000 Immunoprecipitation: 1:50
Molecular Weight25
ImmunogenIgG
FormulationSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C.Do not aliquot the antibody.
StorageSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C.Do not aliquot the antibody.
Regulatory StatusResearch Use Only

Scientific Background

GRB2-related adaptor protein (GRAP) is a member of the GRB2 family of signaling adaptor proteins, and its expression is largely restricted to lymphoid tissues (1,2). Similar to the structure of other members of the GRB2 family of adaptor proteins, GRAP contains a central SH2 domain flanked on either side by SH3 domains that allow for it to directly associate with other signaling molecules (1). Research studies have suggested that, unlike GRB2, GRAP may hinder T cell effector functions by disrupting Ras/MAPK signaling downstream of the T cell receptor signaling complex (3).Trüb, T. et al. (1997)J Biol Chem272, 894-902.Feng, G.S. et al. (1996)J Biol Chem271, 12129-32.Shen, R. et al. (2002)Mol Cell Biol22, 3230-6.Alternate NamesDFNB114; GRAP; GRB2 related adaptor protein; GRB2-related adapter protein; GRB2-related adaptor protein; growth factor receptor-bound protein 2-related adaptor protein; MGC64880; Q13588

Synonyms

DFNB114; GRAP; GRB2 related adaptor protein; GRB2-related adapter protein; GRB2-related adaptor protein; growth factor receptor-bound protein 2-related adaptor protein; MGC64880; Q13588

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