GW182 (E4C7J) Rabbit Monoclonal Antibody#37881,Cell Signaling Technology (CST),37881

GW182/TNRC6 (GW) proteins are essential scaffolding proteins that play a critical role in microRNA (miRNA)-mediated gene silencing, a fundamental mechanism for post-transcriptional regulation of gene expression. GW proteins associate with members of the Argonaute (Ago) protein family to form the miRNA repressor complex (miRISC) and help target miRISC to specific mRNAs (1,2). GW proteins additionally interact with poly(A)-binding protein (PABP) and the CCR4-NOT deadenylase complex to carry out miRNA-mediated silencing and degradation of target mRNA (3). GW and Ago proteins are also known to associate in small cytoplasmic foci known as processing bodies (P-bodies) (4,5). The exact biological role of P-bodies has not yet been determined; these structures may play a role in mRNA degradation and storage, or are simply formed as a consequence of gene silencing (6,7). P-bodies that contain GW proteins are considered to be a distinct subtype referred to as GW/P-bodies, which sequester unique populations of non-translating mRNA (8,9). Three GW paralogs are expressed in vertebrates: GW182 (also referred to as TNRC6A), TNRC6B, and TNRC6C. These paralogs are believed to carry out partially redundant biological functions (10). GW182 is predominantly expressed as a 182 kDa protein but can also be expressed as a 220 kDa isoform (referred to as GW220/TNGW1) that plays a unique role in the formation of GW/P-bodies (8,11).Elkayam, E. et al. (2017)Mol Cell67, 646-658.e3.Eulalio, A. et al. (2009)RNA15, 1433-42.Huntzinger, E. et al. (2013)Nucleic Acids Res41, 978-94.Jakymiw, A. et al. (2005)Nat Cell Biol7, 1267-74.Liu, J. et al. (2005)Nat Cell Biol7, 1261-6.Parker, R. and Sheth, U. (2007)Mol Cell25, 635-46.Eulalio, A. et al. (2007)Mol Cell Biol27, 3970-81.Castilla-Llorente, V. et al. (2012)J Cell Biol198, 529-44.Patel, P.H. et al. (2016)PLoS One11, e0150291.Landthaler, M. et al. (2008)RNA14, 2580-96.Li, S. et al. (2008)J Cell Sci121, 4134-44.Alternate NamesCAG repeat protein 26; CAGH26; CTD-2540M10.1; DKFZp666E117; EDIE; EMSY interactor protein; FAME6; FLJ22043; Glycine-tryptophan protein of 182 kDa; GW1; GW182; GW182 autoantigen; KIAA1460; MGC75384; Protein GW1; TNR6A; TNRC6; TNRC6A; trinucleotide repeat containing 6A; trinucleotide repeat containing adaptor 6A; Trinucleotide repeat-containing gene 6A protein

CAG repeat protein 26; CAGH26; CTD-2540M10.1; DKFZp666E117; EDIE; EMSY interactor protein; FAME6; FLJ22043; Glycine-tryptophan protein of 182 kDa; GW1; GW182; GW182 autoantigen; KIAA1460; MGC75384; Protein GW1; TNR6A; TNRC6; TNRC6A; trinucleotide repeat containing 6A; trinucleotide repeat containing adaptor 6A; Trinucleotide repeat-containing gene 6A protein