Glutamate Dehydrogenase 1/2 (D9F7P) Rabbit Monoclonal Antibody#12793,Cell Signaling Technology (CST),12793

Glutamate dehydrogenase is a mitochondrial enzyme that catalyzes the oxidative deamination of glutamate to α-ketoglutarate through association with the cofactor nicotinamide adenine dinucleotide phosphate (1). Glutamate dehydrogenase is highly expressed in various tissues such as the liver, brain, kidney, heart, pancreas, ovaries, and testis. Two isoforms produced by two distinct genes are found in mammalian tissues. TheGLUD1gene is ubiquitously expressed (2), while theGLUD2gene is specifically expressed in testicular tissues and astrocytes (3,4). Glutamate dehydrogenase links glutamate to the Krebs cycle, thereby playing a critical role in the regulation of energy homeostasis. Research studies have shown that changes in glutamate dehydrogenase activity in pancreatic β-cells can cause a hyperinsulinism syndrome (5).Blumenthal, K.M. et al. (1975)J Biol Chem250, 3644-54.Michaelidis, T.M. et al. (1993)Genomics16, 150-60.Shashidharan, P. et al. (1997)J Neurochem68, 1804-11.Zaganas, I. et al. (2012)Neurochem Int61, 455-62.Karaca, M. et al. (2011)Neurochem Int59, 510-7.Alternate NamesDHE3; epididymis secretory sperm binding protein; epididymis tissue sperm binding protein Li 18mP; GDH; GDH 1; GDH1; GLUD; GLUD1; glutamate dehydrogenase (NAD(P)+); glutamate dehydrogenase 1; Glutamate dehydrogenase 1, mitochondrial; MGC132003

DHE3; epididymis secretory sperm binding protein; epididymis tissue sperm binding protein Li 18mP; GDH; GDH 1; GDH1; GLUD; GLUD1; glutamate dehydrogenase (NAD(P)+); glutamate dehydrogenase 1; Glutamate dehydrogenase 1, mitochondrial; MGC132003