GoInVivo™ Purified anti-human/mouse/rat CD278 (ICOS) anti-CD278 - C398.4A,BioLegend,313542

The C398.4A antibody is useful for flow cytometric analysis and is able to costimulate T cell activation and proliferation. Additional reported applications (for the relevant formats) include: immunoprecipitation1,in vitrocostimulation of T cell activation1,3,4, and spatial biology (IBEX)5,6. The LEAF™ purified antibody (Endotoxin < 0.1 EU/µg, Azide-Free, 0.2 µm filtered) is recommended for functional assays (Cat. No. 313512).

Host

Armenian Hamster

Reactivity

Human, Mouse, Rat

Application

FC -Quality tested

Platform ID

BAB026165579

BioLegend

Headquarters

8999 BioLegend Way San Diego, CA 92121 United States

BioLegend

Contact

Tel: 1-858-455-9588
Fax: +49 (4131) 7023913

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Product Specifications
Scientific Background

Specifications

NameGoInVivo™ Purified anti-human/mouse/rat CD278 (ICOS) anti-CD278 - C398.4A
Cat. No.313542
HostArmenian Hamster
RRIDAB_2728259 (BioLegend Cat. No. 313541)AB_2728260 (BioLegend Cat. No. 313542)AB_2728261 (BioLegend Cat. No. 313543)AB_2728262 (BioLegend Cat. No. 313544)AB_2728263 (BioLegend Cat. No. 313545)AB_2728264 (BioLegend Cat. No. 313546)
IsotypeArmenian Hamster IgG
ReactivityHuman, Mouse, Rat
ApplicationFC -Quality tested
ClonalityMonoclonal
Clone NumberC398.4A
ConcentrationThe antibody is bottled at the concentration indicated on the vial, typically between 2 mg/mL and 3 mg/mL.
TargetCD278
ImmunogenMouse T cell clone D10.G4.1
PurityThe GoInVivo™ antibody was purified by affinity chromatography.
Formulation0.2 µm filtered in phosphate-buffered solution, pH 7.2, containing no preservative.
StorageThe antibody solution should be stored undiluted between 2°C and 8°C. This GoInVivo™ solution contains no preservative; handle under aseptic conditions.
Regulatory StatusResearch Use Only

Scientific Background

ICOS, also known as inducible costimulatory molecule and H4, is a 47-57 kD protein. This protein is homologous to the CD28/CTLA-4 proteins. ICOS is expressed on activated T cells and a subset of thymocytes. It is able to costimulate T cells proliferation. In addition, ICOS is involved in humoral immune responses (B cell germinal center formation). The ICOS ligand is B7h/B7RP-1 or B7-H2. ICOS stimulation has been shown to potentiate TCR-mediated IL-4 and IL-10 production and has been proposed to play a role in Th2 cell development.

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