GoInVivo Purified anti-mouse CD279 PD-1 Antibody anti-CD279 - 29F.1A12,BioLegend,135238

Additional reported applications (for the relevant formats) include: immunohistochemical staining of acetone-fixed frozen tissue3,in vivoblocking of PD-1 binding to its ligands2,3, and spatial biology (IBEX)5,6.

Host

Rat

Reactivity

Mouse

Application

FC - Quality tested

Platform ID

BAB237709047

BioLegend

Headquarters

8999 BioLegend Way San Diego, CA 92121 United States

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Contact

Tel: 1-858-455-9588
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Product Specifications
Scientific Background

Specifications

NameGoInVivo Purified anti-mouse CD279 PD-1 Antibody anti-CD279 - 29F.1A12
Cat. No.135238
HostRat
RRIDAB_2616834 (BioLegend Cat. No. 135233)AB_2616835 (BioLegend Cat. No. 135234)AB_2616836 (BioLegend Cat. No. 135235)AB_2616837 (BioLegend Cat. No. 135236)AB_2616838 (BioLegend Cat. No. 135237)AB_2616839 (BioLegend Cat. No. 135238)
IsotypeRat IgG2a, κ
ReactivityMouse
ApplicationFC - Quality tested
ClonalityMonoclonal
Clone Number29F.1A12
ConcentrationThe antibody is bottled at the concentration indicated on the vial, typically between 2 mg/mL and 3 mg/mL.
TargetCD279
ImmunogenPD-1 cDNA followed by PD-1-Ig fusion protein
PurityThe GoInVivo™ antibody was purified by affinity chromatography.
Formulation0.2 µm filtered in phosphate-buffered solution, pH 7.2, containing no preservative.
StorageThe antibody solution should be stored undiluted between 2°C and 8°C. This GoInVivo™ solution contains no preservative; handle under aseptic conditions.
Regulatory StatusResearch Use Only

Scientific Background

CD279, also known as programmed death-1 (PD-1), is a 50-55 kD glycoprotein belonging to the CD28 family of the Ig superfamily. PD-1 is expressed on activated splenic T and B cells and thymocytes. It is induced on activated myeloid cells as well. PD-1 is involved in lymphocyte clonal selection and peripheral tolerance through binding its ligands, B7-H1 (PD-L1) and B7-DC (PD-L2). It has been reported that PD-1 and PD-L1 interactions are critical to positive selection and play a role in shaping the T cell repertoire. PD-L1 negative costimulation is essential for prolonged survival of intratesticular islet allografts.

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