GoInVivo Purified anti-mouse CD366 Tim-3 Antibody anti-CD366 - RMT3-23,BioLegend,119711

Additional reported applications (for relevant formats) include:in vitro1andin vivo2blocking of Tim-3, and immunohistochemical staining of frozen sections2.

Host

Rat

Reactivity

Mouse

Application

FC - Quality testedBlock, IHC - Reported in the literature, not verified in house

Platform ID

BAB211699009

BioLegend

Headquarters

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Contact

Tel: 1-858-455-9588
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Product Specifications
Scientific Background

Specifications

NameGoInVivo Purified anti-mouse CD366 Tim-3 Antibody anti-CD366 - RMT3-23
Cat. No.119711
HostRat
RRIDAB_2616635 (BioLegend Cat. No. 119712)AB_2616636 (BioLegend Cat. No. 119713)AB_2616637 (BioLegend Cat. No. 119714)AB_2616626 (BioLegend Cat. No. 119709)AB_2616627 (BioLegend Cat. No. 119710)AB_2616628 (BioLegend Cat. No. 119711)
IsotypeRat IgG2a, κ
ReactivityMouse
ApplicationFC - Quality testedBlock, IHC - Reported in the literature, not verified in house
ClonalityMonoclonal
Clone NumberRMT3-23
ConcentrationThe antibody is bottled at the concentration indicated on the vial, typically between 2 mg/mL and 3 mg/mL.
TargetCD366
PurityThe GoInVivo™ antibody was purified by affinity chromatography.
Formulation0.2 µm filtered in phosphate-buffered solution, pH 7.2, containing no preservative.
StorageThe antibody solution should be stored undiluted between 2°C and 8°C. This GoInVivo™ solution contains no preservative; handle under aseptic conditions.
Regulatory StatusResearch Use Only

Scientific Background

CD366 (Tim-3) is a transmembrane protein also known as T cell immunoglobulin and mucin domain containing protein-3. Tim-3 is expressed at high levels on Th1 lymphocytes and CD11b+macrophages. Tim-3 has also been shown to exist as a soluble protein. Cells expressing Tim-3 are present at high levels in the CNS of animals at the onset of experimental autoimmune encephalomyelitis (EAE), a disease mediated by lymphocytes secreting Th1-like cytokines. Tim-3 has been proposed to inhibit Th1-mediated immune responses and promote immunological tolerance.

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