HCFC1 Antibody (Amino-terminal Antigen)#69690,Cell Signaling Technology (CST),69690

Host cell factor C1 (HCFC1) was first identified as the host cell factor for human herpes simplex virus infection. HCFC1 and the viral protein VP16 belong to a multi-protein complex that promotes transcription of viral immediate early genes (1). The relatively large HCFC1 protein contains 6 centrally located 26 amino acid repeats that can be O-GlcNAcylated and subjected to O-linked beta-N-acetylglucosamine transferase (OGT) cleavage (2-4). The resulting amino-terminal (HCFC1-N) and carboxy-terminal (HCFC1-C) fragments are non-covalently associated and play important roles in cell cycle regulation. The HCFC1-N peptide facilitates progression through the G1 phase of the cell cycle while HCFC1-C enables proper mitosis and cytokinesis during the M phase (5-7). As HCFC1 plays an important role in neurodevelopment, mutations in the corresponding gene are associated with neurodevelopmental disorders (e.g., intellectual disability) in humans (8).Vogel, J.L. and Kristie, T.M. (2013)Viruses5, 1272-91.Daou, S. et al. (2011)Proc Natl Acad Sci U S A108, 2747-52.Capotosti, F. et al. (2011)Cell144, 376-88.Lazarus, M.B. et al. (2013)Science342, 1235-9.Julien, E. and Herr, W. (2003)EMBO J22, 2360-9.Julien, E. and Herr, W. (2004)Mol Cell14, 713-25.Zargar, Z. and Tyagi, S. (2012)Transcription3, 187-92.Jolly, L.A. et al. (2015)Hum Mol Genet24, 3335-47.Alternate NamesC1 factor; CFF; HCF; HCF C-terminal chain 1; HCF C-terminal chain 2; HCF C-terminal chain 3; HCF C-terminal chain 4; HCF C-terminal chain 5; HCF C-terminal chain 6; HCF N-terminal chain 1; HCF N-terminal chain 2; HCF N-terminal chain 3; HCF N-terminal chain 4; HCF N-terminal chain 5; HCF N-terminal chain 6; HCF-1; HCF1; HCFC1; HFC1; Host cell factor 1; host cell factor C1; host cell factor C1 (VP16-accessory protein); MGC70925; MRX3; PPP1R89; protein phosphatase 1, regulatory subunit 89; VCAF; VP16 accessory protein; VP16-accessory protein

C1 factor; CFF; HCF; HCF C-terminal chain 1; HCF C-terminal chain 2; HCF C-terminal chain 3; HCF C-terminal chain 4; HCF C-terminal chain 5; HCF C-terminal chain 6; HCF N-terminal chain 1; HCF N-terminal chain 2; HCF N-terminal chain 3; HCF N-terminal chain 4; HCF N-terminal chain 5; HCF N-terminal chain 6; HCF-1; HCF1; HCFC1; HFC1; Host cell factor 1; host cell factor C1; host cell factor C1 (VP16-accessory protein); MGC70925; MRX3; PPP1R89; protein phosphatase 1, regulatory subunit 89; VCAF; VP16 accessory protein; VP16-accessory protein