HDAC1 (D5C6U) Rabbit Monoclonal Antibody (BSA and Azide Free)#51225,Cell Signaling Technology (CST),51225

Acetylation of the histone tail causes chromatin to adopt an "open" conformation, allowing increased accessibility of transcription factors to DNA. The identification of histone acetyltransferases (HATs) and their large multiprotein complexes has yielded important insights into how these enzymes regulate transcription (1,2). HAT complexes interact with sequence-specific activator proteins to target specific genes. In addition to histones, HATs can acetylate nonhistone proteins, suggesting multiple roles for these enzymes (3). In contrast, histone deacetylation promotes a "closed" chromatin conformation and typically leads to repression of gene activity (4). Mammalian histone deacetylases can be divided into three classes on the basis of their similarity to various yeast deacetylases (5). Class I proteins (HDACs 1, 2, 3, and 8) are related to the yeast Rpd3-like proteins, those in class II (HDACs 4, 5, 6, 7, 9, and 10) are related to yeast Hda1-like proteins, and class III proteins are related to the yeast protein Sir2. Inhibitors of HDAC activity are now being explored as potential therapeutic cancer agents (6,7).Marmorstein, R. (2001)Cell Mol Life Sci58, 693-703.Gregory, P.D. et al. (2001)Exp Cell Res265, 195-202.Liu, Y. et al. (2000)Mol Cell Biol20, 5540-53.Cress, W.D. and Seto, E. (2000)J Cell Physiol184, 1-16.Gray, S.G. and Ekström, T.J. (2001)Exp Cell Res262, 75-83.Thiagalingam, S. et al. (2003)Ann. N.Y. Acad. Sci.983, 84-100.Vigushin, D.M. and Coombes, R.C. (2004)Curr Cancer Drug Targets4, 205-18.Alternate NamesDKFZp686H12203; GON-10; HD1; HDAC 1; HDAC1; Histone deacetylase 1; KDAC1; reduced potassium dependency, yeast homolog-like 1; RPD3; RPD3L1

DKFZp686H12203; GON-10; HD1; HDAC 1; HDAC1; Histone deacetylase 1; KDAC1; reduced potassium dependency, yeast homolog-like 1; RPD3; RPD3L1