HDAC3 Rabbit mAb,ABclonal,A28114

Reactivity

Human, Mouse, Rat, Monkey

Application

WB, IF/ICC, IHC-P, ELISA

Conjugate

Unconjugated

Platform ID

BAB410825911

ABclonal

Headquarters

500W Cummings Park, Ste. 6500 Woburn, MA 01801

ABclonal

Contact

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Email:

[email protected]

Product Specifications
Scientific Background
Synonyms

Specifications

NameHDAC3 Rabbit mAb
Cat. No.A28114
Accession NumberO15379
Gene ID (Entrez)8841
IsotypeIgG
ReactivityHuman, Mouse, Rat, Monkey
ConjugationUnconjugated
ApplicationWB, IF/ICC, IHC-P, ELISA
Working DilutionsWB:1:3000 - 1:10000 | IF/ICC:1:100 - 1:200 | IHC-P:1:500 - 1:2000 | ELISA:Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements. For high-ratio antibody dilutions (≥1:10000)，a sequential dilution method is strongly recommended to ensure measurement accuracy.
Clone NumberARC75945
Molecular Weight49 kDa
ImmunogenRecombinant protein (or fragment).This information is considered to be commercially sensitive.
PurityAffinity purification
Appearance/FormLiquid
StorageStore at -20℃. Avoid freeze / thaw cycles.; Buffer: PBS with 0.09% Sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Regulatory StatusResearch Use Only

Scientific Background

Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene.

Synonyms

HD3; RPD3; KDAC3; RPD3-2

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