HDAC4 Antibody (YA391),MedChemexpress,HY-P80153

The HDAC4 protein plays a crucial role in the deacetylation of lysine residues on the N-terminal region of core histones (H2A, H2B, H3, and H4), contributing to the epigenetic repression that underlies essential cellular processes, including transcriptional regulation, cell cycle progression, and developmental events. Functioning within large multiprotein complexes, histone deacetylases, including HDAC4, orchestrate these intricate regulatory mechanisms. Specifically, HDAC4 is involved in muscle maturation through its interaction with myocyte enhancer factors (MEF2A, MEF2C, and MEF2D). Furthermore, HDAC4 plays a pivotal role in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. Notably, HDAC4 deacetylates HSPA1A and HSPA1B at 'Lys-77,' leading to their preferential binding to the co-chaperone STUB1, demonstrating the protein's diverse and nuanced involvement in cellular processes and molecular interactions.