HIF1 beta antibody [2B10],Genetex,GTX22771

Host

Mouse

Reactivity

Human, Mouse, Rat, Xenopus, Fish, Primate

Application

WB ICC/IF IHC-P IP Gel supershift assays IHC

Conjugate

Unconjugated

Platform ID

BAB051098663

Genetex

Headquarters

2456 Alton Pkwy Irvine, CA 92606 USA

Genetex

Contact

Tel: 1-949-553-1900
Fax: 1-949-309-2888

Email:

[email protected]

Product Specifications
Scientific Background
Synonyms

Specifications

NameHIF1 beta antibody [2B10]
Cat. No.GTX22771
Gene ID (Entrez)405
HostMouse
IsotypeIgG1
ReactivityHuman, Mouse, Rat, Xenopus, Fish, Primate
ConjugationUnconjugated
ApplicationWB ICC/IF IHC-P IP Gel supershift assays IHC
ClonalityMonoclonal
Concentration1 mg/ml (Please refer to the vial label for the specific concentration.)
TargetARNT
ImmunogenSynthetic peptide corresponding to residues C N(771) S Y N N E E F P D L T M F P P F S E(789) of human ARNT.
PurityPurified IgG
Appearance/FormLiquid
FormulationPBS, 0.1% BSA,0.05% Sodium azide
StorageStore as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Regulatory StatusResearch Use Only

Scientific Background

This gene encodes a protein containing a basic helix-loop-helix domain and two characteristic PAS domains along with a PAC domain. The encoded protein binds to ligand-bound aryl hydrocarbon receptor and aids in the movement of this complex to the nucleus, where it promotes the expression of genes involved in xenobiotic metabolism. This protein is also a co-factor for transcriptional regulation by hypoxia-inducible factor 1. Chromosomal translocation of this locus with the ETV6 (ets variant 6) gene on chromosome 12 have been described in leukemias. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2013]

Synonyms

aryl hydrocarbon receptor nuclear translocator , HIF-1-beta , HIF-1beta , HIF1-beta , HIF1B , HIF1BETA , TANGO , bHLHe2

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