HRP Anti-LRP1 antibody [EPR3724],Abcam,AB195569

Patented technology Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb ® patents . What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including: - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies .

Host

Rabbit

Reactivity

Human, Human, Mouse, Rat

Application

WB, IHC-P

Conjugate

HRP

Platform ID

BAB528524331

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Abcam

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Email:

[email protected]

Product Specifications
Scientific Background

Specifications

NameHRP Anti-LRP1 antibody [EPR3724]
Cat. No.AB195569
HostRabbit
IsotypeIgG
ReactivityHuman, Human, Mouse, Rat
ConjugationHRP
ApplicationWB, IHC-P
ClonalityMonoclonal
Clone NumberEPR3724
Concentration0.5 mg/mL Batch dependent concentration
ImmunogenThe exact immunogen used to generate this antibody is proprietary information.
PurityAffinity purification Protein A
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7.4 Preservative: 0.1% Proclin 300 Solution Constituents: PBS, 30% Glycerol (glycerin, glycerine), 1% BSA
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells (PubMed : 11907044, PubMed : 12713657). Required for early embryonic development (By similarity). Involved in cellular lipid homeostasis. Involved in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha 2-macroglobulin), as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. Acts as an LRPAP1 alpha-2-macroglobulin receptor (PubMed : 1702392, PubMed : 26142438). Acts as TAU/MAPT receptor and controls the endocytosis of TAU/MAPT as well as its subsequent spread (PubMed : 32296178). May modulate cellular events, such as APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling as well as neurotransmission (PubMed : 12888553). Also acts as a receptor for IGFBP3 to mediate cell growth inhibition (PubMed : 9252371).. (Microbial infection) Functions as a receptor for Pseudomonas aeruginosa exotoxin A. See full target information LRP1

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