HSPB8/HSP22 Rabbit pAb- ABclonal,ABclonal,A2514

Reactivity

Human, Mouse, Rat

Application

WB, IF-P, IHC-P, ELISA

Conjugate

Unconjugated

Platform ID

BAB750019342

ABclonal

Headquarters

500W Cummings Park, Ste. 6500 Woburn, MA 01801

ABclonal

Contact

Tel:
Fax:

Email:

[email protected]

Product Specifications
Scientific Background
Synonyms

Specifications

NameHSPB8/HSP22 Rabbit pAb- ABclonal
Cat. No.A2514
Accession NumberQ9UJY1
Gene ID (Entrez)26353
RRIDAB_2764405
IsotypeIgG
ReactivityHuman, Mouse, Rat
ConjugationUnconjugated
ApplicationWB, IF-P, IHC-P, ELISA
Working DilutionsWB:1:1000 - 1:5000 | IF-P:1:50 - 1:200 | IHC-P:1:50 - 1:200 | ELISA:Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Molecular Weight22kDa
ImmunogenRecombinant protein (or fragment).This information is considered to be commercially sensitive.
PurityAffinity purification
Appearance/FormLiquid
StorageStore at -20℃. Avoid freeze / thaw cycles.; Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide (as specified on the Certificate of Analysis), pH 7.3.
Regulatory StatusResearch Use Only

Scientific Background

The protein encoded by this gene belongs to the superfamily of small heat-shock proteins containing a conservative alpha-crystallin domain at the C-terminal part of the molecule. The expression of this gene in induced by estrogen in estrogen receptor-positive breast cancer cells, and this protein also functions as a chaperone in association with Bag3, a stimulator of macroautophagy. Thus, this gene appears to be involved in regulation of cell proliferation, apoptosis, and carcinogenesis, and mutations in this gene have been associated with different neuromuscular diseases, including Charcot-Marie-Tooth disease.

Synonyms

H11; HMN2; CMT2L; DHMN2; E2IG1; HMN2A; HSP22; HSPB8/HSP22

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