HUWE1 antibody,Genetex,GTX85051

Host

Rabbit

Reactivity

Human, Mouse, Rat

Application

WB ICC/IF ELISA

Conjugate

Unconjugated

Platform ID

BAB198028103

Genetex

Headquarters

2456 Alton Pkwy Irvine, CA 92606 USA

Genetex

Contact

Tel: 1-949-553-1900
Fax: 1-949-309-2888

Email:

[email protected]

Product Specifications
Scientific Background
Synonyms

Specifications

NameHUWE1 antibody
Cat. No.GTX85051
Gene ID (Entrez)10075
HostRabbit
IsotypeIgG
ReactivityHuman, Mouse, Rat
ConjugationUnconjugated
ApplicationWB ICC/IF ELISA
ClonalityPolyclonal
Concentration1 mg/ml (Please refer to the vial label for the specific concentration.)
TargetH
ImmunogenHUWE1 antibody was raised against a 19 amino acid synthetic peptide from near the carboxy terminus of human HUWE1.The immunogen is located within amino acids 4250 - 4300 of HUWE1.
PurityPurified by antigen-affinity chromatography
Appearance/FormLiquid
FormulationPBS,0.02% Sodium azide
StorageStore as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Regulatory StatusResearch Use Only

Scientific Background

The ARF tumor suppressor is a critical regulator of p53 stability. In addition to p53, ARF1 binds to other proteins such as MDM2 and ARF-BP1, a large protein containing HECT, UBA and WWE motifs. ARF-BP1 directly binds and ubiquitinates p53; this activity is inhibited by ARF, indicating that ARF-BP1 is a critical mediator of the p53-dependent and p53-independent tumor suppressor functions of ARF. ARF-BP1 can also catalyze the polyubiquitination of Mcl-1, an anti-apoptotic Bcl-2 family member involved in DNA damage-induced apoptosis. Elimination of ARF-BP1 expression by RNA interference stabilized Mcl-1 protein, resulting in an attenuation of apoptosis induced by DNA-damage agents.

Synonyms

HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1 , ARF-BP1 , HECTH9 , HSPC272 , Ib772 , LASU1 , MULE , URE-B1 , UREB1

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