Helios (D8W4X) Rabbit Monoclonal Antibody (SignalFlexTMAlexa Fluor®700 Conjugate)#88789,Cell Signaling Technology (CST),88789

Helios (D8W4X) XP®Rabbit mAb (SignalFlexTM Alexa Fluor®700 Conjugate) recognizes endogenous levels of total Helios protein.

Host

Rabbit

Reactivity

Human, Mouse

Conjugate

SignalFlexTMAlexa Fluor®700 Conjugate

Platform ID

BAB321734902

Cell Signaling Technology (CST)

Headquarters

3 Trask Lane Danvers, MA 01923

Cell Signaling Technology (CST)

Contact

Tel: 877-616-2355,978-867-2388
Fax: 877-616-2355

Email:

[email protected]

Product Specifications
Scientific Background
Synonyms

Specifications

NameHelios (D8W4X) Rabbit Monoclonal Antibody (SignalFlexTMAlexa Fluor®700 Conjugate)#88789
Cat. No.88789
Accession NumberQ9UKS7
Gene ID (Entrez)22807
HostRabbit
SensitivityEndogenous
ReactivityHuman, Mouse
ConjugationSignalFlexTMAlexa Fluor®700 Conjugate
ImmunogenIgG
FormulationSignalFlexTM conjugates are produced using highly validated Cell Signaling Technology®primary antibodies and conjugation methods that have been rigorously tested, ensuring high-quality conjugates and lot-to-lot consistency. These conjugates are quality control tested by size exclusion chromatography (SEC) to determine antibody integrity. However, they are not tested on specific assays.Optimal dilutions/concentrations should be determined by the end user. When performing flow cytometry, we recommend using an isotype control conjugate at the same concentration as the antibody conjugate.
StorageSupplied in PBS (pH 7.2), less than 0.1% sodium azide, and 2 mg/mL BSA. Store at 4°C.Do not aliquot the antibody. Protect from light. Do not freeze.
Regulatory StatusResearch Use Only

Scientific Background

Helios (Ikaros family zinc finger 2, IKZF2) is an Ikaros family transcription factor composed of several zinc fingers that mediate DNA binding and homodimerization or heterodimerization with other Ikaros family proteins (1,2). In the hematopoietic system, Helios expression is restricted to T cells and early hematopoietic progenitors (1,2). In regulatory T cells, expression of Helios contributes to an anergic phenotype by binding to the IL-2 promoter and suppressing IL-2 transcription (3). In addition, alteration of the corresponding Helios geneIKZF2is one hallmark of low-hypodiploid acute lymphoblastic leukemia (4).Hahm, K. et al. (1998)Genes Dev12, 782-96.Kelley, C.M. et al. (1998)Curr Biol8, 508-15.Baine, I. et al. (2013)J Immunol190, 1008-16.Holmfeldt, L. et al. (2013)Nat Genet45, 242-52.Alternate NamesANF1A2; HELIOS; IKAROS family zinc finger 2; IKAROS family zinc finger 2 (Helios); Ikaros family zinc finger protein 2; IKZF2; MGC34330; zinc finger DNA binding protein Helios; Zinc finger protein Helios; zinc finger protein, subfamily 1A, 2 (Helios); ZNF1A2; ZNFN1A2

Synonyms

ANF1A2; HELIOS; IKAROS family zinc finger 2; IKAROS family zinc finger 2 (Helios); Ikaros family zinc finger protein 2; IKZF2; MGC34330; zinc finger DNA binding protein Helios; Zinc finger protein Helios; zinc finger protein, subfamily 1A, 2 (Helios); ZNF1A2; ZNFN1A2

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