Heme Oxygenase 1 Antibody (YA6087),MedChemexpress,HY-P86395

Heme Oxygenase 1 Antibody (YA6087) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Heme Oxygenase 1.

Host

Rabbit

Reactivity

Human,Mouse,Rat

Application

WB,IHC-P,ICC/IF,IP,ELISA

Conjugate

Non-conjugated

Platform ID

BAB288000299

Master of Bioactive Molecules

MedChemexpress

Master of Bioactive Molecules

Headquarters

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Contact

Tel: 609-228-6898
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Product Specifications
Scientific Background
Synonyms

Specifications

NameHeme Oxygenase 1 Antibody (YA6087)
Cat. No.HY-P86395
Accession NumberP09601
Gene ID (Entrez)3162
HostRabbit
RRIDAB_3719145
IsotypeIgG/Kappa
ReactivityHuman,Mouse,Rat
ConjugationNon-conjugated
ApplicationWB,IHC-P,ICC/IF,IP,ELISA
Working DilutionsIHC-P: 1:2000-1:10000; WB: 1:2000-1:10000; ICC/IF: 1:200-1:1000; ELISA: 1:5000-1:20000; IP: 1:50-1:200
ClonalityMonoclonal
Clone NumberYA6087
Molecular WeightPredicted band size: 33 kDa; Observed band size: 33 kDa
PurityProtein A
Appearance/FormLiquid
ShippingShipping with blue ice.
FormulationSupplied in PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
StorageStored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Regulatory StatusResearch Use Only

Scientific Background

HO-1 protein, through its catalytic activity, orchestrates the oxidative cleavage of heme at the alpha-methene bridge carbon, leading to the release of carbon monoxide (CO) and the generation of biliverdin IXalpha. Simultaneously, it liberates the central heme iron chelate as ferrous iron. This enzymatic process not only provides a mechanism for the breakdown of heme but also exerts a cytoprotective effect by preventing the sensitization of cells to programmed cell death or apoptosis. The ability of HO-1 to catabolize free heme underscores its crucial role in cellular defense mechanisms, contributing to cell survival and protection against various stressors.

Synonyms

Heme oxygenase 1 (HO-1) (EC 1.14.99.3)

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