Hexokinase-1 (HK1) Antibody,Abbexa,abx015885

The hexokinases utilize Mg-ATP as a phosphoryl donor to catalyze the first step of intracellular glucose metabolism, the conversion of glucose to glucose- 6-phosphate.Four hexokinase isoenzymes have been identified, including hexokinase I (HXK I), hexokinase II (HXK II), hexokinase III (HXK III) and hexokinase IV (HXK IV, also designated glucokinase or GCK).Hexokinases I-III each contain an N-terminal cluster of hydrophobic amino acids.Glucokinase lacks the N-terminal hydrophobic cluster.The hydrophobic cluster is thought to be necessary for membrane binding.This is substantiated by the finding that glucokinase has lower affinity for glucose than do the other hexokinases.HK I has been shown to be expressed in brain, kidney and heart tissues as well as in hepatoma cell lines.