Histone H2A.XS139ph (phospho Ser139) antibody,Genetex,GTX127342

Host

Rabbit

Reactivity

Zebrafish

Application

WB ICC/IF IHC-P IHC-Fr IHC-Wm IHC

Conjugate

Unconjugated

Platform ID

BAB713304560

Genetex

Headquarters

2456 Alton Pkwy Irvine, CA 92606 USA

Genetex

Contact

Tel: 1-949-553-1900
Fax: 1-949-309-2888

Email:

[email protected]

Product Specifications
Scientific Background
Synonyms

Specifications

NameHistone H2A.XS139ph (phospho Ser139) antibody
Cat. No.GTX127342
Gene ID (Entrez)394048
HostRabbit
IsotypeIgG
ReactivityZebrafish
ConjugationUnconjugated
ApplicationWB ICC/IF IHC-P IHC-Fr IHC-Wm IHC
ClonalityPolyclonal
Concentration0.47 mg/ml (Please refer to the vial label for the specific concentration.)
Targeth2afx
ImmunogenCarrier-protein conjugated synthetic peptide surrounding phospho Ser139 of zebrafish Histone H2A.X. The exact sequence is proprietary.
PurityPurified by antigen-affinity chromatography.
Appearance/FormLiquid
FormulationPBS, 1% BSA, 20% Glycerol,0.025% ProClin 300
StorageStore as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Regulatory StatusResearch Use Only

Scientific Background

Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation.

Synonyms

H2A histone family, member X , zgc:56329

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