Human EpCAM x E. coli β-Gal Bispecific Antibody - Negative Control,InvivoGen,bimab-ecambg-01

Anti-hEpCAM-βGalis a bispecific antibody that recognizes two sites: human epithelial cell adhesion molecule (hEpCAM) andE. coliβ-galactosidase (β-Gal). It is used as a negative control for the Anti-hEpCAM-CD3 bispecific antibody that, like solitomab, engages unstimulated T cells to proliferate and exert cytotoxic activity on EpCAM-positive tumor cells [1]. Human EpCAM (also known as CD326, Trop1) is a transmembrane, 40 kDa glycoprotein highly abundant in almost all human carcinomas, including colon, prostate, ovarian, or breast cancer [2]. In healthy tissue, EpCAM expression is generally low [1,2]. In cancer, EpCAM overexpression is responsible for tumor proliferation, invasion, and migration. Since it is often correlated with a poor prognosis, EpCAM represents an attractive therapeutic target [1].