Human Protein phosphatase 1 regulatory subunit 15B (PPP1R15B) ELISA Kit,Abbkine,KTE61191

• Do not mix components from different kit lots or use reagents beyond the kit expiration date.• Allow all reagents to warm to room temperature for at least 30 minutes before opening.• Pre-rinse the pipet tip with reagent, use fresh pipet tips for each sample, standard and reagent to avoid contamination. • Unused wells must be kept desiccated at 4 °C in the sealed bag provided.• Mix Thoroughly is very important for the result. It is recommended using low frequency oscillator or slight hand shaking every 10 minutes.• It is recommended that all samples and standards be assayed in duplicate or triplicate.

Platform ID

BAB328818856

Abbkine

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3052 Stroop Hill Road, Apt 203, Atlanta 30303, Georgia, United States of America

Abbkine

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Tel: +1-404-854-0155
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Email:

[email protected]

Product Specifications
Scientific Background
Synonyms

Specifications

NameHuman Protein phosphatase 1 regulatory subunit 15B (PPP1R15B) ELISA Kit
Cat. No.KTE61191
Accession NumberQ5SWA1
ShippingThe unopened kit should be stored at 2 - 8°C. After opening, please store refer to protocols.
StorageThe unopened kit should be stored at 2 - 8°C. After opening, please store refer to protocols.
Regulatory StatusResearch Use Only

Scientific Background

PPP1R15B promotes dephosphorylation of the transcription initiation factor EIF2-alpha (EIF2S1) through recruitment of protein phosphatase-1 (PP1) catalytic subunits. Ppp1r15b -/- mice showed low hematocrit and red blood cell count, with qualitative abnormalities in red cell size and shape. Histologic examination of mutant liver was consistent with compensatory proliferation of blood precursors. Ppp1r15b -/- mouse embryo fibroblasts showed elevated Eif2-alpha phosphorylation. Ppp1r15b -/- embryos that were also homozygous for an Eif2-alpha mutation that prevented Eif2-alpha phosphorylation were normalized, including elevated birth size and restored red blood cell count, compared with Ppp1r15b -/- embryos with wildtype Eif2-alpha.

Synonyms

PPP1R15B; FLJ14744; protein phosphatase 1; regulatory subunit 15B

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