IBTK antibody,Genetex,GTX66301

Host

Rabbit

Reactivity

Human

Application

WB

Conjugate

Unconjugated

Platform ID

BAB168542263

Genetex

Headquarters

2456 Alton Pkwy Irvine, CA 92606 USA

Genetex

Contact

Tel: 1-949-553-1900
Fax: 1-949-309-2888

Email:

[email protected]

Product Specifications
Scientific Background
Synonyms

Specifications

NameIBTK antibody
Cat. No.GTX66301
Gene ID (Entrez)25998
HostRabbit
IsotypeIgG
ReactivityHuman
ConjugationUnconjugated
ApplicationWB
ClonalityPolyclonal
ConcentrationBatch dependent (Please refer to the vial label for the specific concentration.)
TargetIBTK
ImmunogenRecombinant funsion protein containing a sequence corresponding to amino acids 900-1200 of human IBTK (NP_056340.2).
PurityPurified by affinity chromatography
Appearance/FormLiquid
FormulationPBS, 50% Glycerol,0.02% Sodium azide
StorageStore as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Regulatory StatusResearch Use Only

Scientific Background

Bruton tyrosine kinase (BTK) is a protein tyrosine kinase that is expressed in B cells, macrophages, and neutrophils. The protein encoded by this gene binds to BTK and downregulates BTK's kinase activity. In addition, the encoded protein disrupts BTK-mediated calcium mobilization and negatively regulates the activation of nuclear factor-kappa-B-driven transcription. This gene has a pseudogene on chromosome 18. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2014]

Synonyms

inhibitor of Bruton tyrosine kinase , BTBD26 , BTKI

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