IDO (D8W5E) Rabbit Monoclonal Antibody#51851,Cell Signaling Technology (CST),51851

INDO/IDO1/indoleamine 2,3-dioxygenase (IDO) is an IFN-γ-inducible enzyme that catalyzes the rate-limiting step of tryptophan degradation (1). IDO is upregulated in many tumors and in dendritic cells in tumor-draining lymph nodes. Elevated tryptophan catabolism in these cells leads to tryptophan starvation of T cells, limiting T cell proliferation and activation (2). Therefore, IDO is considered an immunosuppressive molecule, and research studies have shown that upregulation of IDO is a mechanism of cancer immune evasion (3). The gastrointestinal stromal tumor drug, imatinib, was found to act, in part, by reducing IDO expression, resulting in increased CD8+T cell activation and induction of apoptosis in regulatory T cells (4). In addition to its enzymatic activity, IDO was recently shown to have signaling capability through an immunoreceptor tyrosine-based inhibitory motif (ITIM) that is phosphorylated by Fyn in response to TGF-β. This leads to recruitment of SHP-1 and activation of the noncanonical NF-κB pathway (5).Yasui, H. et al. (1986)Proc Natl Acad Sci U S A83, 6622-6.Mellor, A.L. et al. (2003)Adv Exp Med Biol527, 27-35.Prendergast, G.C. (2008)Oncogene27, 3889-900.Balachandran, V.P. et al. (2011)Nat Med17, 1094-100.Pallotta, M.T. et al. (2011)Nat Immunol12, 870-8.Alternate NamesI23O1; Ido; IDO-1; Ido1; Indo; indole 2,3-dioxygenase; Indoleamine 2,3-dioxygenase 1; indoleamine-pyrrole 2,3 dioxygenase; Indoleamine-pyrrole 2,3-dioxygenase; OTTMUSP00000022551

I23O1; Ido; IDO-1; Ido1; Indo; indole 2,3-dioxygenase; Indoleamine 2,3-dioxygenase 1; indoleamine-pyrrole 2,3 dioxygenase; Indoleamine-pyrrole 2,3-dioxygenase; OTTMUSP00000022551