IFN-beta1 (D2J1D) Rabbit Monoclonal Antibody (BSA and Azide Free)#15454,Cell Signaling Technology (CST),15454

The type I interferon (IFN) family includes IFN-β1 and IFN-α1 through IFN-α13 in humans and IFN-α1 through IFN-α14 in mice. Type I IFN is produced following detection of pathogen-associated molecular patterns (PAMPs) and is important for induction of antiviral genes, activation of dendritic cells, and initiation of adaptive immunity (1, 2). Type I IFNs signal through the IFN alpha receptor (IFNAR), which is a heterodimer composed of IFNAR1 and IFNAR2. Activation of IFNAR leads to formation of the nuclear complex IFN-stimulated gene factor 3 (ISGF3), which consists of STAT1, STAT2, and IRF-9 (3, 4). ISGF3 binds to IFN-stimulated response elements (ISREs) to initiate transcription of interferon-stimulated genes (3).Paludan, S.R. and Bowie, A.G. (2013)Immunity38, 870-80.Ivashkiv, L.B. and Donlin, L.T. (2014)Nat Rev Immunol14, 36-49.Levy, D.E. et al. (1989)Genes Dev3, 1362-71.Qureshi, S.A. et al. (1995)Proc Natl Acad Sci U S A92, 3829-33.Alternate NamesIfb; IFN-b; IFN-beta; Ifnb; Ifnb1; Interferon beta; interferon beta 1, fibroblast

Ifb; IFN-b; IFN-beta; Ifnb; Ifnb1; Interferon beta; interferon beta 1, fibroblast