IL-18 (F8I2S) Rabbit Monoclonal Antibody#72554,Cell Signaling Technology (CST),72554

Interleukin-18 (IL-18), originally known as interferon-gamma inducing factor (IGIF), is part of the IL-superfamily of cytokines (1,2). This proinflammatory cytokine is synthesized as an inactive precursor which requires cleavage by Caspase-1 to become an active, mature molecule, which is secreted by monocytes and macrophages (3,4,6). It induces IFNγ production in T-helper-1 (Th1) cells and natural killer (NK) cells, and can regulate innate immunity via both Th1 and Th2 responses (4,5). Elevated IL-18 levels are associated with autoimmune disease, but may be balanced by binding to IL-18 binding protein (IL-18BP), which along with IL-18 neutralizing antibodies, are being examined in clinical trials (6,7).Okamura, H. et al. (1995)Nature378, 88-91.Ushio, S. et al. (1996)J Immunol156, 4274-9.Ghayur, T. et al. (1997)Nature386, 619-23.Dinarello, C.A. (1999)Methods19, 121-32.Nakanishi, K. et al. (2001)Annu Rev Immunol19, 423-74.Novick, D. et al. (1999)Immunity10, 127-36.Dinarello, C.A. et al. (2013)Front Immunol4, 289.Alternate NamesIFN-gamma-inducing factor; Igif; IL 18; Il-; IL-1 gamma; IL-18; Il18; Interferon gamma-inducing factor; interferon-gamma-inducing factor; interleukin 18; Interleukin-1 gamma; Interleukin-18

IFN-gamma-inducing factor; Igif; IL 18; Il-; IL-1 gamma; IL-18; Il18; Interferon gamma-inducing factor; interferon-gamma-inducing factor; interleukin 18; Interleukin-1 gamma; Interleukin-18