IL-33 (E2T5L) Rabbit Monoclonal Antibody#88513,Cell Signaling Technology (CST),88513

IL-33 (Interleukin-33, NF-HEV) is a nuclear cytokine that is part of the IL-1 family (1,2). Originally discovered as the ‘nuclear factor from high endothelial venules,’ it is widely expressed by endothelial cells as well as epithelial barrier tissues (1,5). IL-33 is involved in regulating type 2-associated innate immune responses (2,4). It is the ligand for ST2 which, along with IL-1RAcP, forms the IL-33R signaling complex (2,3). IL-33 functions as an alarmin upon cellular damage or stress, and is associated with allergic inflammation and asthma (5,6).Baekkevold, E.S. et al. (2003)Am J Pathol163, 69-79.Schmitz, J. et al. (2005)Immunity23, 479-90.Chackerian, A.A. et al. (2007)J Immunol179, 2551-5.Smithgall, M.D. et al. (2008)Int Immunol20, 1019-30.Moussion, C. et al. (2008)PLoS One3, e3331.Cayrol, C. and Girard, J.P. (2014)Curr Opin Immunol31, 31-7.Alternate NamesC9orf26; DKFZp586H0523; DVS27; DVS27-related protein; IL-1F11; IL-33; IL1F11; IL33; interleukin 33; Interleukin-1 family member 11; Interleukin-33; Interleukin-33 (109-270); Interleukin-33 (95-270); Interleukin-33 (99-270); NF-HEV; NFEHEV; NFHEV; nuclear factor for high endothelial venules; Nuclear factor from high endothelial venules; RP11-575C20.2

C9orf26; DKFZp586H0523; DVS27; DVS27-related protein; IL-1F11; IL-33; IL1F11; IL33; interleukin 33; Interleukin-1 family member 11; Interleukin-33; Interleukin-33 (109-270); Interleukin-33 (95-270); Interleukin-33 (99-270); NF-HEV; NFEHEV; NFHEV; nuclear factor for high endothelial venules; Nuclear factor from high endothelial venules; RP11-575C20.2