IL18 Antibody (YA8855),MedChemexpress,HY-P89407

IL18 is a pro-inflammatory cytokine primarily involved in epithelial barrier repair, polarized T-helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, it forms a signaling ternary complex that activates NF-kappa-B, triggering the synthesis of inflammatory mediators. It synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells and NK cells. Additionally, IL18 is involved in the transduction of inflammation downstream of pyroptosis, where its mature form is specifically released into the extracellular milieu through the gasdermin-D (GSDMD) pore.