INF2 (E7H5D) Rabbit Monoclonal Antibody#41081,Cell Signaling Technology (CST),41081

INF2 (E7H5D) Rabbit Monoclonal Antibody recognizes endogenous levels of total INF2 protein. INF2 isoforms 1 and 2 appear as a doublet in the 170 kDa range using western blot analysis. This antibody also detects a band at approximately 100 kDa of unknown origin. This band may be a carboxy-terminal cleavage product of INF2.

Host

Rabbit

Reactivity

Human

Application

Western Blotting: 1:1000 Immunoprecipitation: 1:50

Platform ID

BAB357817574

Cell Signaling Technology (CST)

Headquarters

3 Trask Lane Danvers, MA 01923

Cell Signaling Technology (CST)

Contact

Tel: 877-616-2355,978-867-2388
Fax: 877-616-2355

Email:

[email protected]

Product Specifications
Scientific Background
Synonyms

Specifications

NameINF2 (E7H5D) Rabbit Monoclonal Antibody#41081
Cat. No.41081
Accession NumberQ27J81
Gene ID (Entrez)64423
HostRabbit
SensitivityEndogenous
ReactivityHuman
ApplicationWestern Blotting: 1:1000 Immunoprecipitation: 1:50
Molecular Weight170
ImmunogenIgG
FormulationSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C.Do not aliquot the antibody.
StorageSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C.Do not aliquot the antibody.
Regulatory StatusResearch Use Only

Scientific Background

Inverted formin 2 (INF2) is a member of the formin family of actin assembly factors. INF2 regulates multiple cellular processes, including mitochondrial fission and vesicle trafficking. INF2 also regulates microtubule stability in conjunction with the formin mDia1 and IQGAP1 (1).Mutations in INF2 have been linked to kidney disease and neuropathy in humans (2). INF2 stimulates Drp1-mediated and Drp1-independent mitochondrial division (3). Speckle-type POZ Protein (SPOP), a potential driver in human prostate cancer, regulates INF2 activity through ubiquitination, affecting INF2-mediated migration, invasion, and mitochondrial fission in prostate cancer (4). In thyroid cancer, JNK2 signaling mediates INF2-related mitochondrial fission to promote apoptosis (5).Bartolini, F. et al. (2016)Mol Biol Cell27, 1797-808.Hegsted, A. et al. (2017)Cytoskeleton (Hoboken)74, 405-19.Chakrabarti, R. et al. (2018)J Cell Biol217, 251-68.Jin, X. et al. (2017)PLoS Genet13, e1006748.Li, X. et al. (2019)J Cell Physiol, doi: 10.1002/jcp.28287.Alternate NamesC14orf151; C14orf173; CMTDIE; DKFZp762A0214; FLJ22056; FSGS5; HBEAG-binding protein 2 binding protein C; HBEBP2-binding protein C; INF2; inverted formin 2; Inverted formin-2; inverted formin, FH2 and WH2 domain containing; MGC13251; pp9484

Synonyms

C14orf151; C14orf173; CMTDIE; DKFZp762A0214; FLJ22056; FSGS5; HBEAG-binding protein 2 binding protein C; HBEBP2-binding protein C; INF2; inverted formin 2; Inverted formin-2; inverted formin, FH2 and WH2 domain containing; MGC13251; pp9484

Category Paths

Request a product

Please provide the required information below so that we can quickly source your products.