IRAK1 (D51G7) Rabbit Monoclonal Antibody (Biotinylated)#11123,Cell Signaling Technology (CST),11123

IRAK1 (D51G7) Rabbit Monoclonal Antibody (Biotinylated) detects endogenous levels of total IRAK1 protein.

Host

Rabbit

Reactivity

Human, Mouse, Monkey

Platform ID

BAB885465561

Cell Signaling Technology (CST)

Headquarters

3 Trask Lane Danvers, MA 01923

Cell Signaling Technology (CST)

Contact

Tel: 877-616-2355,978-867-2388
Fax: 877-616-2355

Email:

[email protected]

Product Specifications
Scientific Background
Synonyms

Specifications

NameIRAK1 (D51G7) Rabbit Monoclonal Antibody (Biotinylated)#11123
Cat. No.11123
Accession NumberP51617
Gene ID (Entrez)51617, 3654
HostRabbit
SensitivityEndogenous
ReactivityHuman, Mouse, Monkey
Molecular Weight78-105
ImmunogenIgG
FormulationBiotinylated antibodies are ideal for immunoassay technologies and high-throughput ELISA platforms that require antibody pairs where both antibodies are from the same host. Platforms utilizing biotinylated antibodies include, but are not limited to, MSD, xMAP, Quanterix Simoa, AlphaLISA, AlphaScreen, HTRF, LANCE, and TR-FRET.Optimal dilutions/working concentrations should be determined by the end user. Pleasecontact usif you require the antibody clone biotinylated at a different concentration, a carrier-free formulation, or a more customized packaging solution.
StorageSupplied in 140 mM NaCl, 3 mM KCI, 10 mM sodium phosphate (pH 7.4) dibasic, 2 mM potassium phosphate monobasic, 2 mg/mL BSA, and 50% glycerol. Store at –20°C.Do not aliquot the antibody.
Regulatory StatusResearch Use Only

Scientific Background

Interleukin-1 (IL-1) receptor-associated kinase (IRAK) is a serine/threonine-specific kinase that can be coprecipitated in an IL-1-inducible manner with the IL-1 receptor (1). The mammalian family of IRAK molecules contains four members (IRAK1, IRAK2, IRAK3/IRAK-M, and IRAK4). The binding of IL-1 to IL-1 receptor type I (IL-1RI) initiates the formation of a complex that includes IL-1RI, AcP, MyD88, and IRAKs (2). IRAK undergoes autophosphorylation shortly after IL-1 stimulation. The subsequent events involve IRAK dissociation from the IL-1RI complex, its ubiquitination, and its association with two membrane-bound proteins: TAB2 and TRAF6. The resulting IRAK-TRAF6-TAB2 complex is then released into the cytoplasm where it activates protein kinase cascades, including TAK1, IKKs, and the stress-activated kinases (3).Dinarello, C.A. (1996)Blood87, 2095-147.Takaesu, G. et al. (2001)Mol Cell Biol21, 2475-84.Janssens, S. and Beyaert, R. (2003)Mol Cell11, 293-302.Alternate Namesinterleukin 1 receptor associated kinase 1; Interleukin-1 receptor-associated kinase 1; IRAK; IRAK-1; IRAK1; pelle; Pelle homolog

Synonyms

interleukin 1 receptor associated kinase 1; Interleukin-1 receptor-associated kinase 1; IRAK; IRAK-1; IRAK1; pelle; Pelle homolog

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