IRF-5 (E7F9W) Rabbit Monoclonal Antibody (SignalFlexTMPacific BlueTMConjugate)#74323,Cell Signaling Technology (CST),74323

IRF-5 (E7F9W) Rabbit mAb (SignalFlexTM Pacific BlueTM Conjugate) recognizes endogenous levels of total IRF-5 protein.

Host

Rabbit

Reactivity

Human

Conjugate

SignalFlexTMPacific BlueTMConjugate

Platform ID

BAB448196700

Cell Signaling Technology (CST)

Headquarters

3 Trask Lane Danvers, MA 01923

Cell Signaling Technology (CST)

Contact

Tel: 877-616-2355,978-867-2388
Fax: 877-616-2355

Email:

[email protected]

Product Specifications
Scientific Background
Synonyms

Specifications

NameIRF-5 (E7F9W) Rabbit Monoclonal Antibody (SignalFlexTMPacific BlueTMConjugate)#74323
Cat. No.74323
Accession NumberQ13568
Gene ID (Entrez)13568, 3663
HostRabbit
SensitivityEndogenous
ReactivityHuman
ConjugationSignalFlexTMPacific BlueTMConjugate
ImmunogenIgG
FormulationSignalFlexTM conjugates are produced using highly validated Cell Signaling Technology®primary antibodies and conjugation methods that have been rigorously tested, ensuring high-quality conjugates and lot-to-lot consistency. These conjugates are quality control tested by size exclusion chromatography (SEC) to determine antibody integrity. However, they are not tested on specific assays.Optimal dilutions/concentrations should be determined by the end user. When performing flow cytometry, we recommend using an isotype control conjugate at the same concentration as the antibody conjugate.
StorageSupplied in PBS (pH 7.2), less than 0.1% sodium azide, and 2 mg/mL BSA. Store at 4°C.Do not aliquot the antibody. Protect from light. Do not freeze.
Regulatory StatusResearch Use Only

Scientific Background

Interferon regulatory factors (IRFs) comprise a family of transcription factors that function within the Jak/Stat pathway to regulate interferon (IFN) and IFN-inducible gene expression in response to viral infection (1). IRFs play an important role in pathogen defense, autoimmunity, lymphocyte development, cell growth, and susceptibility to transformation. The IRF family includes nine members: IRF-1, IRF-2, IRF-9/ISGF3γ, IRF-3, IRF-4 (Pip/LSIRF/ICSAT), IRF-5, IRF-6, IRF-7, and IRF-8/ICSBP. All IRF proteins share homology in their amino-terminal DNA-binding domains. IRF family members regulate transcription through interactions with proteins that share similar DNA-binding motifs, such as IFN-stimulated response elements (ISRE), IFN consensus sequences (ICS), and IFN regulatory elements (IRF-E) (2).Taniguchi, T. et al. (2001)Annu Rev Immunol19, 623-55.Honda, K. and Taniguchi, T. (2006)Nat Rev Immunol6, 644-58.Alternate NamesInterferon regulatory factor 5; IRF-5; IRF5; SLEB10

Synonyms

Interferon regulatory factor 5; IRF-5; IRF5; SLEB10

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