IRF-5 (E9I4Z) Rabbit Monoclonal Antibody (Alexa Fluor®647 Conjugate)#71383,Cell Signaling Technology (CST),71383

IRF-5 (E9I4Z) Rabbit Monoclonal Antibody (Alexa Fluor®647 Conjugate) recognizes human IRF-5 protein and is also reactive with mouse IRF-5 protein.

Host

Rabbit

Reactivity

Human, Mouse

Application

Flow Cytometry (Fixed/Permeabilized): 1:50

Platform ID

BAB073209194

Cell Signaling Technology (CST)

Headquarters

3 Trask Lane Danvers, MA 01923

Cell Signaling Technology (CST)

Contact

Tel: 877-616-2355,978-867-2388
Fax: 877-616-2355

Email:

[email protected]

Product Specifications
Scientific Background
Synonyms

Specifications

NameIRF-5 (E9I4Z) Rabbit Monoclonal Antibody (Alexa Fluor®647 Conjugate)#71383
Cat. No.71383
Accession NumberQ13568
Gene ID (Entrez)13568, 3663
HostRabbit
SensitivityEndogenous
ReactivityHuman, Mouse
ApplicationFlow Cytometry (Fixed/Permeabilized): 1:50
ImmunogenIgG
FormulationSupplied in PBS (pH 7.2), less than 0.1% sodium azide, and 2 mg/mL BSA. Store at 4°C.Do not aliquot the antibody. Protect from light. Do not freeze.
StorageSupplied in PBS (pH 7.2), less than 0.1% sodium azide, and 2 mg/mL BSA. Store at 4°C.Do not aliquot the antibody. Protect from light. Do not freeze.
Regulatory StatusResearch Use Only

Scientific Background

Interferon regulatory factors (IRFs) comprise a family of transcription factors that function within the Jak/Stat pathway to regulate interferon (IFN) and IFN-inducible gene expression in response to viral infection (1). IRFs play an important role in pathogen defense, autoimmunity, lymphocyte development, cell growth, and susceptibility to transformation. The IRF family includes nine members: IRF-1, IRF-2, IRF-9/ISGF3γ, IRF-3, IRF-4 (Pip/LSIRF/ICSAT), IRF-5, IRF-6, IRF-7, and IRF-8/ICSBP. All IRF proteins share homology in their amino-terminal DNA-binding domains. IRF family members regulate transcription through interactions with proteins that share similar DNA-binding motifs, such as IFN-stimulated response elements (ISRE), IFN consensus sequences (ICS), and IFN regulatory elements (IRF-E) (2).Taniguchi, T. et al. (2001)Annu Rev Immunol19, 623-55.Honda, K. and Taniguchi, T. (2006)Nat Rev Immunol6, 644-58.Alternate NamesInterferon regulatory factor 5; IRF-5; IRF5; SLEB10

Synonyms

Interferon regulatory factor 5; IRF-5; IRF5; SLEB10

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