IRF-6 Antibody#6948,Cell Signaling Technology (CST),6948

Interferon regulatory factors (IRFs) comprise a family of transcription factors that function within the Jak/Stat pathway to regulate interferon (IFN) and IFN-inducible gene expression in response to viral infection (1). IRFs play an important role in pathogen defense, autoimmunity, lymphocyte development, cell growth, and susceptibility to transformation. The IRF family includes nine members: IRF-1, IRF-2, IRF-9/ISGF3γ, IRF-3, IRF-4 (Pip/LSIRF/ICSAT), IRF-5, IRF-6, IRF-7, and IRF-8/ICSBP. All IRF proteins share homology in their amino-terminal DNA-binding domains. IRF family members regulate transcription through interactions with proteins that share similar DNA-binding motifs, such as IFN-stimulated response elements (ISRE), IFN consensus sequences (ICS), and IFN regulatory elements (IRF-E) (2).While IRF family members generally function in innate immune responses, IRF-6 has not been associated with that role. Original studies of IRF-6 found that mutation of theIRF-6gene caused Van der Woude Syndrome, an autosomal dominant disorder resulting in mouth abnormalities, including cleft lip and palate (3). IRF-6 knockouts show a hyperproliferative epidermis that fails to undergo keratinocyte differentiation (4). IRF-6 has also been found to interact with the mammary tumor suppressor maspin, and like maspin, is expressed in normal mammary epithelial cells but reduced or absent in breast carcinoma (5). Cellular proliferation may promote IRF-6 phosphorylation, leading to proteasomal-dependent degradation (6).Taniguchi, T. et al. (2001)Annu Rev Immunol19, 623-55.Honda, K. and Taniguchi, T. (2006)Nat Rev Immunol6, 644-58.Kondo, S. et al. (2002)Nat Genet32, 285-9.Richardson, R.J. et al. (2006)Nat Genet38, 1329-34.Bailey, C.M. et al. (2005)J Biol Chem280, 34210-7.Bailey, C.M. et al. (2008)Mol Cell Biol28, 2235-43.Alternate NamesInterferon regulatory factor 6; IRF-6; IRF6; LPS; OFC6; PIT; PPS; PPS1; VWS; VWS1

Interferon regulatory factor 6; IRF-6; IRF6; LPS; OFC6; PIT; PPS; PPS1; VWS; VWS1