Iba1/AIF-1 (E4O4W) Mouse Chimeric Monoclonal Antibody#58410,Cell Signaling Technology (CST),58410

Ionized calcium-binding adaptor molecule 1 (Iba1), also known as allograft inflammatory factor 1 (AIF-1), is an evolutionarily conserved cytoplasmic calcium binding protein containing a central pair of EF-hand calcium binding motifs (1,2). Iba1/AIF-1 was originally cloned from activated macrophages in human atherosclerotic allogenic heart grafts undergoing chronic transplant rejection as well as from rat monocytes (3,4). Its function is not very well understood, but Iba1/AIF-1 expression is upregulated in response to interferon-gamma and, therefore, could modulate macrophage-dependent immune response (3). As an F-actin-binding protein, Iba1/AIF-1 may function to remodel the actin cytoskeleton and contribute to morphological changes that correlate with various microglial/macrophage states (5). Iba1/AIF-1 is also uniquely expressed in cells of monocytic lineage and is, therefore, widely used as a marker for microglia/macrophages in the brain and other tissue (6).Schulze, J.O. et al. (2008)FEBS J275, 4627-40.Deininger, M.H. et al. (2002)FEBS Lett514, 115-21.Utans, U. et al. (1995)J Clin Invest95, 2954-62.Imai, Y. et al. (1996)Biochem Biophys Res Commun224, 855-62.Kanazawa, H. et al. (2002)J Biol Chem277, 20026-32.Ito, D. et al. (1998)Brain Res Mol Brain Res57, 1-9.Alternate NamesAIF-1; AIF1; Allograft inflammatory factor 1; G1; IBA 1; IBA-1; IBA1; interferon gamma responsive transcript; Ionized calcium-binding adapter molecule 1; IRT-1; IRT1; Protein G1

AIF-1; AIF1; Allograft inflammatory factor 1; G1; IBA 1; IBA-1; IBA1; interferon gamma responsive transcript; Ionized calcium-binding adapter molecule 1; IRT-1; IRT1; Protein G1