Integrin beta8 (D1V7M) Rabbit Monoclonal Antibody#88300,Cell Signaling Technology (CST),88300

Integrin αvβ8 facilitates activation and release of TGF-β, which has immunosuppressive effects (1). Deletion of integrin β8 from dendritic cells led to development of inflammatory bowel disease and autoimmunity in mice, as well as failure to induce regulatory T cells that require TGF-β for development (2). TGF-β is also involved in Th17 cell differentiation. Mice lacking expression of integrin β8 on dendritic cells fail to develop Th17 cells and are protected from Th17-mediated autoimmune disease (3). Regulatory T cells express high levels of integrin αvβ8, which enables them to suppress pathogenic T cell activation by activating latent TGF-β (4). Integrin β8 is also essential for vascular morphogenesis as integrin β8-deficient mice are embryonic or perinatal lethal and exhibit insufficient and abnormal vascular morphogenesis (5).Mu, D. et al. (2002)J Cell Biol157, 493-507.Travis, M.A. et al. (2007)Nature449, 361-5.Melton, A.C. et al. (2010)J Clin Invest120, 4436-44.Worthington, J.J. et al. (2015)Immunity42, 903-15.Zhu, J. et al. (2002)Development129, 2891-903.Alternate Names4832412O06Rik; Integrin beta; integrin beta 8; Integrin beta-8; ITB8; Itgb8

4832412O06Rik; Integrin beta; integrin beta 8; Integrin beta-8; ITB8; Itgb8