Jab1 antibody [6C3.38],Genetex,GTX70205

Host

Mouse

Reactivity

Human, Mouse

Application

WB IP IHC

Conjugate

Unconjugated

Platform ID

BAB484546830

Genetex

Headquarters

2456 Alton Pkwy Irvine, CA 92606 USA

Genetex

Contact

Tel: 1-949-553-1900
Fax: 1-949-309-2888

Email:

[email protected]

Product Specifications
Scientific Background
Synonyms

Specifications

NameJab1 antibody [6C3.38]
Cat. No.GTX70205
Gene ID (Entrez)10987
HostMouse
IsotypeIgG2a
ReactivityHuman, Mouse
ConjugationUnconjugated
ApplicationWB IP IHC
ClonalityMonoclonal
Concentration1 mg/ml (Please refer to the vial label for the specific concentration.)
TargetCOPS5
ImmunogenThe full-length mouse JAB-1 gene expressed in E. coli.
PurityProtein G purifiedFrom tissue culture supernatant
Appearance/FormLiquid
FormulationPBS,No preservatives
StorageStore as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Regulatory StatusResearch Use Only

Scientific Background

The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein is reported to be involved in the degradation of cyclin-dependent kinase inhibitor CDKN1B/p27Kip1. It is also known to be an coactivator that increases the specificity of JUN/AP1 transcription factors. [provided by RefSeq, Jul 2008]

Synonyms

COP9 signalosome subunit 5 , CSN5 , JAB1 , MOV-34 , SGN5

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