Jak1 (6G4) Rabbit Monoclonal Antibody (Biotinylated)#88617,Cell Signaling Technology (CST),88617

Jak1 (6G4) Rabbit Monoclonal Antibody (Biotinylated) detects endogenous levels of total Jak1 protein. This antibody does not cross react with other Jak family members.

Host

Rabbit

Reactivity

Human, Mouse, Rat

Platform ID

BAB635840381

Cell Signaling Technology (CST)

Headquarters

3 Trask Lane Danvers, MA 01923

Cell Signaling Technology (CST)

Contact

Tel: 877-616-2355,978-867-2388
Fax: 877-616-2355

Email:

[email protected]

Product Specifications
Scientific Background
Synonyms

Specifications

NameJak1 (6G4) Rabbit Monoclonal Antibody (Biotinylated)#88617
Cat. No.88617
Accession NumberP23458
Gene ID (Entrez)23458, 3716
HostRabbit
SensitivityEndogenous
ReactivityHuman, Mouse, Rat
Molecular Weight130
ImmunogenIgG
FormulationBiotinylated antibodies are ideal for immunoassay technologies and high-throughput ELISA platforms that require antibody pairs where both antibodies are from the same host. Platforms utilizing biotinylated antibodies include, but are not limited to, MSD, xMAP, Quanterix Simoa, AlphaLISA, AlphaScreen, HTRF, LANCE, and TR-FRET.Optimal dilutions/working concentrations should be determined by the end user. Pleasecontact usif you require the antibody clone biotinylated at a different concentration, a carrier-free formulation, or a more customized packaging solution.
StorageSupplied in 140 mM NaCl, 3 mM KCl, 10 mM sodium phosphate (pH 7.4) dibasic, 2 mM potassium phosphate monobasic, 2 mg/mL BSA, and 50% glycerol. Store at –20°C.Do not aliquot the antibody.
Regulatory StatusResearch Use Only

Scientific Background

Members of the Janus family of tyrosine kinases (Jak1, Jak2, Jak3, and Tyk2) are activated by ligands binding to a number of associated cytokine receptors (1). Upon cytokine receptor activation, Jak proteins become autophosphorylated and phosphorylate their associated receptors to provide multiple binding sites for signaling proteins. These associated signaling proteins, such as Stats (2), Shc (3), insulin receptor substrates (4), and focal adhesion kinase (FAK) (5), typically contain SH2 or other phospho-tyrosine-binding domains.Leonard, W.J. and O'Shea, J.J. (1998)Annu Rev Immunol16, 293-322.Darnell, J.E. (1997)Science277, 1630-5.VanderKuur, J. et al. (1995)J Biol Chem270, 7587-93.Argetsinger, L.S. et al. (1995)J Biol Chem270, 14685-92.Zhu, T. et al. (1998)J Biol Chem273, 10682-9.Alternate NamesAIIDE; JAK-1; JAK1; JAK1A; JAK1B; Janus kinase 1; Janus kinase 1 (a protein tyrosine kinase); JTK3; Tyrosine-protein kinase JAK1

Synonyms

AIIDE; JAK-1; JAK1; JAK1A; JAK1B; Janus kinase 1; Janus kinase 1 (a protein tyrosine kinase); JTK3; Tyrosine-protein kinase JAK1

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