Jak1 Antibody#3332,Cell Signaling Technology (CST),3332

Jak1 Antibody detects endogenous levels of total Jak1 protein.

Reactivity

Human, Mouse

Application

Western Blotting: 1:1000 Simple WesternTM: 1:10 - 1:50

Platform ID

BAB046310847

Cell Signaling Technology (CST)

Headquarters

3 Trask Lane Danvers, MA 01923

Cell Signaling Technology (CST)

Contact

Tel: 877-616-2355,978-867-2388
Fax: 877-616-2355

Email:

[email protected]

Product Specifications
Scientific Background
Synonyms

Specifications

NameJak1 Antibody#3332
Cat. No.3332
Accession NumberP23458
Gene ID (Entrez)23458, 3716
SensitivityEndogenous
ReactivityHuman, Mouse
ApplicationWestern Blotting: 1:1000 Simple WesternTM: 1:10 - 1:50
Molecular Weight130
FormulationSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.
StorageSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.
Regulatory StatusResearch Use Only

Scientific Background

Members of the Janus family of tyrosine kinases (Jak1, Jak2, Jak3, and Tyk2) are activated by ligands binding to a number of associated cytokine receptors (1). Upon cytokine receptor activation, Jak proteins become autophosphorylated and phosphorylate their associated receptors to provide multiple binding sites for signaling proteins. These associated signaling proteins, such as Stats (2), Shc (3), insulin receptor substrates (4), and focal adhesion kinase (FAK) (5), typically contain SH2 or other phospho-tyrosine-binding domains.Leonard, W.J. and O'Shea, J.J. (1998)Annu Rev Immunol16, 293-322.Darnell, J.E. (1997)Science277, 1630-5.VanderKuur, J. et al. (1995)J Biol Chem270, 7587-93.Argetsinger, L.S. et al. (1995)J Biol Chem270, 14685-92.Zhu, T. et al. (1998)J Biol Chem273, 10682-9.Alternate NamesAIIDE; JAK-1; JAK1; JAK1A; JAK1B; Janus kinase 1; Janus kinase 1 (a protein tyrosine kinase); JTK3; Tyrosine-protein kinase JAK1

Synonyms

AIIDE; JAK-1; JAK1; JAK1A; JAK1B; Janus kinase 1; Janus kinase 1 (a protein tyrosine kinase); JTK3; Tyrosine-protein kinase JAK1

Category Paths

Request a product

Please provide the required information below so that we can quickly source your products.