KDM2A Antibody (YA2812),MedChemexpress,HY-P83067

The related gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by The related gene belongs to the Fbls class and, in addition to an F-box, contains at least six highly derelated generated leucine-rich repeats. The family member plays a role in epirelated genetic silencing. It nucleates at CpG islands and specifically demethylates both mono- and di-methylated lysine-36 of histone H3. Alternative splicing results in multiple transcript variants.

FBL7; CXXC8; FBL11; FBXL11; JHDM1A; LILINA