KIRAVIA Blue 520™ anti-mouse/human CD282 (TLR2) Recombinant Antibody, CD282, QA16A01,BioLegend,153009

Blocking of IL-6 and TNF-a production induced by P3CSK4on RAW264.7 cells was observed during development.

Host

Mouse

Reactivity

Mouse, Human

Application

FC - Quality tested

Platform ID

BAB186999606

BioLegend

Headquarters

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Contact

Tel: 1-858-455-9588
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Product Specifications
Scientific Background

Specifications

NameKIRAVIA Blue 520™ anti-mouse/human CD282 (TLR2) Recombinant Antibody, CD282, QA16A01
Cat. No.153009
HostMouse
RRIDAB_2894420 (BioLegend Cat. No. 153009)AB_2894420 (BioLegend Cat. No. 153010)
IsotypeMouse IgG1, κ
ReactivityMouse, Human
ApplicationFC - Quality tested
ClonalityRecombinant
Clone NumberQA16A01
Concentration0.2 mg/mL
TargetCD282
ImmunogenRecombinant extracellular domain of murine TLR2
PurityThe antibody was purified by affinity chromatography and conjugated with KIRAVIA Blue 520™ under optimal conditions.
FormulationPhosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
StorageThe antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light.Do not freeze.
Regulatory StatusResearch Use Only

Scientific Background

CD282 (Toll-like receptor 2, TLR2) is an 85kDa, type I transmembrane protein, with 14 leucine-rich repeats (LRR) in the extracellular domain and a toll/IL-1R (TIR) in the cytoplasmic region. TLR2 is expressed by monocytes/macrophages, dendritic cells, granulocytes, endothelial cell and epithelial cells. TLR2 associates with TLR1 and TLR6 in the cell surface and is involved in the recognition of pathogen-associated molecular patterns (PAMPs) such as peptidoglycan, lipoteihoic acid (LTA), lipoarabinomanan, lipoproteins, and LPS from certain Gram-negative bacteria, yeast, spirochete and fungi.

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