KLF4 Antibody (YA321),MedChemexpress,HY-P80201

KLF4 Antibody (YA321) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to KLF4.

Host

Rabbit

Reactivity

Human,Mouse

Application

WB,ICC/IF,IHC-P

Conjugate

Non-conjugated

Platform ID

BAB876330409

Suppliers

(1)

Biomedical Life sciences

91-9676853503

[email protected]
Country:India
City:Madīnat Ḩamad
Plot No.A-2811121/A&B/3.IP NACHARAM. ALA NACHARAM, Road N0-15, Hyderabad Medchal Malkajgiri, Telangana-500076
Master of Bioactive Molecules

MedChemexpress

Master of Bioactive Molecules

Headquarters

1 Deer Park Drive, Suite FMONMOUTH JUNCTION, NI 08852, USA

MedChemexpress

Contact

Tel: 609-228-6898
Fax: 609-228-5909

Email:

[email protected]

Product Specifications
Verification Image
Scientific Background

Specifications

NameKLF4 Antibody (YA321)
Cat. No.HY-P80201
Accession NumberO43474
Gene ID (Entrez)9314
HostRabbit
RRIDAB_3676039
IsotypeIgG
SensitivityEndogenous
ReactivityHuman,Mouse
ConjugationNon-conjugated
ApplicationWB,ICC/IF,IHC-P
Working DilutionsWB: 1:500-1:2000; ICC/IF: 1:50-1:200; IHC-P: 1:50-1:200
ClonalityRecombinant,Monoclonal
Clone NumberYA321
Molecular WeightPredicted band size: 55 kDa; Observed band size: 55 kDa
ImmunogenSynthetic peptide corresponding to Human KLF4.AA range:320-360.
PurityProtein A affinity purified.
Appearance/FormLiquid
ShippingShipping with blue ice.
FormulationSupplied in 1*TBS (pH7.4), 0.05% BSA and 40% Glycerol. Preservative: 0.05% Sodium Azide.
StorageStored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Regulatory StatusResearch Use Only

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Scientific Background

GKLF is a transcription factor capable of functioning as both an activator and a repressor. It binds to the 5'-CACCC-3' core sequence and its own gene promoter to activate self-transcription. This factor regulates key transcription factors during embryonic development, playing critical roles in maintaining embryonic stem cells and suppressing their differentiation. GKLF is essential for establishing skin barrier function, postnatal ocular surface maturation/maintenance, epithelial cell differentiation, and potentially skeletal/kidney development. It also contributes to p53/TP53 transcriptional downregulation. by similar: Shares partial functional overlap with other KLF family transcription factors.

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