[KO Validated] AMPKα1 Rabbit mAb,ABclonal,A28094

Reactivity

Human, Mouse, Rat

Application

WB, IP, IF/ICC, IHC-P, ELISA

Conjugate

Unconjugated

Platform ID

BAB905878287

ABclonal

Headquarters

500W Cummings Park, Ste. 6500 Woburn, MA 01801

ABclonal

Contact

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Email:

[email protected]

Product Specifications
Scientific Background
Synonyms

Specifications

Name[KO Validated] AMPKα1 Rabbit mAb
Cat. No.A28094
Accession NumberQ13131
Gene ID (Entrez)5562
IsotypeIgG
ReactivityHuman, Mouse, Rat
ConjugationUnconjugated
ApplicationWB, IP, IF/ICC, IHC-P, ELISA
Working DilutionsWB:1:5000 - 1:20000 | IP:0.5μg-4μg antibody for 200μg-400μg extracts of whole cells | IF/ICC:1:100 - 1:200 | IHC-P:1:300 - 1:1200 | ELISA:Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Clone NumberARC73664
Molecular Weight64kDa
ImmunogenSynthetic peptide. This information is considered to be commercially sensitive.
PurityAffinity purification
Appearance/FormLiquid
StorageStore at -20℃. Avoid freeze / thaw cycles.; Buffer: PBS with 0.09% Sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Regulatory StatusResearch Use Only

Scientific Background

The protein encoded by this gene belongs to the ser/thr protein kinase family. It is the catalytic subunit of the 5'-prime-AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor conserved in all eukaryotic cells. The kinase activity of AMPK is activated by the stimuli that increase the cellular AMP/ATP ratio. AMPK regulates the activities of a number of key metabolic enzymes through phosphorylation. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. Alternatively spliced transcript variants encoding distinct isoforms have been observed.

Synonyms

AMPK; AMPKa1; AMPK alpha 1

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